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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Yan Wu

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Open access Sep 2026

Ribosome dynamics at the conserved PGP motif governs 2A peptide-bond-skipping efficiency

Abstract Viral 2A oligopeptides drive an unusual ribosome recoding event in which peptide-bond formation fails at a conserved PG↓P motif, producing two discrete proteins without canonical termination. Despite decades of study, the molecular basis of 2A-mediated peptide-bond skipping remains poorly understood. Here, we...

Xin-Cheng Wu, Saori Uematsu, Yan Wu et al. · 0 citations

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