Author

Yan-Xia Chen

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Open access Sep 2026

Tet2 deficiency drives age-related heterogeneous progression of myeloid neoplasms through epigenetic-immune microenvironment imbalance

A hematopoietic specific Tet2 conditional knockout mouse model recapitulates core clinical features of elderly Tet2-mutated myeloid neoplasms and provides a preclinical platform for mechanistic investigation and the development of epigenetic and immune-targeted precision therapies.

Yan-Xia Chen, Li Yu, Rui Yang et al. · Journal of Translational Med... · 0 citations

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