Author

Yan Xu

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Review Open access Sep 2026

The single-cell immune atlas of bacterial pneumonia: from inflammatory cell infiltration to treatable cell states

Bacterial pneumonia remains a major cause of infectious mortality, and antimicrobial resistance has intensified interest in host-directed therapy (HDT). Recent bronchoalveolar lavage fluid (BALF) and peripheral blood atlases (2024–2025) provide single-cell evidence from human disease, but the main translational gap is...

Hang Chen, Yan Xu, Zhi-Wei Guan et al. · Frontiers in Cellular and In... · 0 citations

Review Open access Aug 2026

Temporal regulation of wnt signaling in alveolar development and regeneration: mechanistic insights and therapeutic advances in chronic lung diseases

Wnt signaling coordinates lung specification, alveolar maturation, adult epithelial maintenance, and injury repair, but its biological output varies with developmental or disease stage, anatomical compartment, responding cell type, receptor context, and signal duration. This review organizes current evidence using a te...

Ming-Yue Ren, Gui-Jun Song, Yan Xu et al. · Frontiers in Cell and Develo... · 0 citations