Single-cell transcriptomics identifies a putative perivascular macrophage–endothelial MIF–ACKR3 axis associated with endothelial activation in acute traumatic brain injury
Background Blood–brain barrier (BBB) disruption is a hallmark of acute traumatic brain injury (TBI), yet the immune–vascular mechanisms underlying endothelial dysfunction remain incompletely understood. Perivascular macrophages (PVMs) are strategically positioned to modulate cerebrovascular homeostasis, but their role...