Author

Yan-Yun Sun

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Open access Aug 2026

Chemogenetic Manipulation of mPFC Neurons Counteracts Cognitive Deficits But Leaves Sleep Disturbances Unaffected in a Mouse Model of Chronic Intermittent Hypoxia

The mPFC is a critical hub for CIH-induced cognitive impairment, and its targeted inhibition can restore cognitive and synaptic function, however, sleep architecture disruptions are governed by distinct mechanisms, indicating a dissociation between CIH-mediated cognitive and sleep pathologies.

Guo Pei, Xin-Yue Li, Yuan-Yuan Wang et al. · Journal of Neuroscience · 0 citations

Aug 2026

Distinct Transcriptional States of TDP-43 Pathology in an Alzheimer's Disease Mouse Model.

A transcriptional framework linking early TDP-43 stress responses to pathological aggregation in AD is provided, and potential upstream therapeutic targets are revealed, including ERK1/2, PI3K, small GTPases, and mRNA splicing pathways.

Ji-Chuan Liu, Wen-Jin Liu, Li-Qiang Yu et al. · Neuroscience Bulletin · 0 citations