Yan Zhang

Penciclovir-Fumaric Acid (2:1) Cocrystal: Crystal Structure, Hirshfeld Surface Analysis, and Release Behavior

Penciclovir (PCV), a nucleoside antiviral drug, exhibits extremely low oral bioavailability (<5%), which makes it difficult to achieve effective plasma concentrations. To address this limitation, a novel pharmaceutical cocrystal of PCV with fumaric acid (FA) was successfully prepared via a suspension method. The newl...