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Author

Yanzhe Huang

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Open access Aug 2026

Selective Redox Tuning Enables Potent Intracellular Reduction of Nicotinamide Cytosine Dinucleotide

The ubiquitous nicotinamide adenine dinucleotide (NAD) engages in diverse biological processes, leading to non-selective energy transfer toward target synthetic reactions. To achieve selective energy transfer in complex biological systems, we previously constructed artificial systems mediated by the non-natural cofacto...

Xiao-Jia Guo, Yan-Zhe Huang, Ying-Han Hu et al. · 0 citations
Jul 2026

Engineering alanine dehydrogenase to favor nicotinamide cytosine dinucleotide for formate-driven alanine synthesis.

To bypass the availability limitation and metabolic crosstalk associated with native reduced nicotinamide adenine dinucleotide (NADH) pools in L-alanine production, a non-natural cofactor system may offer a compelling strategy to secure independent reducing power. Here, we engineered an alanine dehydrogenase (AlaDH) fr...

Ying-Han Hu, Xiao-Jia Guo, Xue-Ying Wang et al. · 0 citations

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