Open access
Aug 2026
Procyanidin C1 activates Nrf2/HO-1 to preserve in vivo mitochondrial homeostasis and counter chondrocyte senescence in osteoarthritis
Findings establish a mechanistic link between PCC1, Nrf2/HO-1 activation and chondrocyte mitochondrial homoeostasis in osteoarthritis, and support Nrf2-directed senotherapies as a regenerative strategy to slow OA progression.
Yubiao Zhang, Mao Chen, Wenxiang Cai et al.
· Cell Death & Disease · 1 citation