Jul 2026
Functional noncoding variants within the TBX1 enhancer contribute to tetralogy of Fallot.
This study demonstrates the involvement of noncoding variants in the TBX1 enhancer in TOF pathogenesis, highlighting the feasibility of using organoids to decipher the underlying mechanisms of unconserved noncoding regions in developmental malformations.
Jimiao Gao, T. Jiang, Yingyi Quan et al.
· Science China Life Sciences · 0 citations