Yanan Bian

Decoding the crosstalk: interplay between macrophage programmed cell death networks and cholesterol efflux

A macrophage death-mode bifurcation framework centered on caspase-8 activity, RIPK1 ubiquitination, mitochondrial stress, oxidative stress thresholds, and autophagic flux is proposed to provide a basis for future studies integrating cell-death regulation, cholesterol transport, and plaque stability.