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Author

Yang Gao

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Open access Aug 2026

PER2 suppresses glioma progression through physical association with KRAS and attenuation of PI3K-AKT-mTOR pathway activation

Glioblastoma (GBM) is the most aggressive primary brain tumor with poor prognosis. The circadian gene PER2 has been reported to exhibit tumor-suppressive functions, while KRAS is a key oncogenic driver. This study aims to investigate the mechanistic interaction between PER2 and KRAS in gliomagenesis. PER2 expression wa...

Yang Gao, Pengfei Bie, Yan-Bin Zhao et al. · 0 citations

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