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Yang Gu

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Jul 2026

Machine-Learning-Enabled Rapid Evolution of Photoenzymes for the Asymmetric Synthesis of gem-Difluorophosphonates.

A small-sample, accelerated evolution strategy that integrates focused rational iterative site-specific mutagenesis (FRISM) with the EVOLVEpro model is reported, providing a robust, "lightweight" machine learning framework for the rapid development of new-to-nature photoenzymatic transformations.

Hongkui Wang, Jiafan Xu, Jiahai Zhou et al. · 0 citations