Author

Yang-Hao Zheng

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Review Open access Nov 2026

Molecular Diagnostic Biomarkers in Autism Spectrum Disorder: From Multi-Omics Signatures to Precision Therapeutic Targets

Autism spectrum disorder (ASD) is a systemic multi-organ condition characterized by profound biological heterogeneity. Clinical management currently faces a bottleneck due to reliance on subjective behavioral phenotyping rather than objective molecular markers. This review synthesizes breakthroughs in ASD diagnostics,...

Yang-Hao Zheng, Ming-Zhe Zhao · Molecules · 0 citations

Oct 2026

Discovery of a fluorinated benzoxathiazine AMPA receptor PAM that stabilizes the GluA2 dimer interface and displays antidepressant-like effects.

Positive allosteric modulators (PAMs) of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors hold significant therapeutic promise for neuropsychiatric disorders driven by synaptic dysfunction. Building upon our previously established oxathiazine-dioxide scaffold, we designed and synthesized a novel se...

Long Wei, Xue-Li Yu, Yang-Hao Zheng et al. · European journal of medicina... · 0 citations