Yang Jiang

Monomeric C-Reactive Protein Potentiates Microglia-Mediated Neuroinflammation in Alzheimer's Disease via the PLC-PKC-MAPK-NF-κB Pathway.

Neuroinflammation is a major contributor to the pathogenesis of Alzheimer's disease (AD). Although elevated serum C-reactive protein (CRP) is associated with increased AD risk, the specific conformational forms of CRP operative in the brain and their underlying mechanisms remain unclear. Here, we combined human brain t...