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Author

Yang Li

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Aug 2026

PARP7 Enhances Doxorubicin-Induced Cardiomyocyte Ferroptosis and Cardiotoxicity by ADP-Ribosylation-Dependent Suppression of GPX4 Activity.

It is demonstrated that PARP7 is robustly and selectively upregulated in cardiomyocytes following DOX exposure, and the PARP7-GPX4 axis is defined as a mechanistically grounded, therapeutically targetable pathway in cardio-oncology.

Yiting Lyu, Lin-Tao Wang, Xiao-Wen Shi et al. · 0 citations

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