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Review Jul 2026

Polygenic risk scores in major depressive disorder: A systematic review across diagnostic, treatment, course/severity, and subtype domains.

Polygenic risk score evidence was clearest for MDD diagnostic status and showed a tentative pattern for overall symptom burden and larger, ancestrally diverse studies with standardised endpoints and transparent PRS methods are needed.

Yang Li, Rui Liu, Yi-Jing Guo et al. · 0 citations

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