Tumor-derived amyloid-β drives TREM2+ macrophages immunosuppression in cholangiocarcinoma.
Cholangiocarcinoma (CCA) is an aggressive malignancy with limited therapeutic options. In this study, we explored the role of TREM2+ tumor-associated macrophages (TAMs) in modulating the immune microenvironment and their impact on anti-PD-1 therapy. Using single-cell RNA sequencing data and immunohistochemical analysis...