Author

Yang Luo

2 papers indexed here

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Open access Oct 2026

Reconstructing donor genotypes from scRNA-seq for downstream eQTL and HLA–TCR analysis

Single-cell eQTL studies can reveal heterogeneous genetic effects on gene expression that vary with cell type, but their wider application has been constrained by the frequent absence of matched genotype data. Here, we present single-cell Transcriptome Allelic Prediction and Association Studies (scTAPAS), a bioinformat...

Hannah Kockelbergh, Jennifer Astley, K. Kichula et al. · bioRxiv · 0 citations

Open access Oct 2026

Rank-based integration identifies convergent disease mechanisms across omics

The rapid growth of omics studies offers new opportunities to uncover disease mechanisms, yet findings from individual studies or single omics may be influenced by cohort-, platform– and layer-specific variation. Integrating evidence across studies and omics layers can reveal robust biological signals that are reproduc...

Z. Qiu, D. Palmer, L. Jostins et al. · bioRxiv · 0 citations