Author

Yang-Ni Li

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Sep 2026

Sephin1 directly targets PHB2 to activate PINK1-PRKN-dependent mitophagy and alleviate α-synuclein neurotoxicity in Parkinson's disease models.

Parkinson's disease (PD) is a prevalent age-related neurodegenerative disorder characterized by pathological α-synuclein aggregation, mitochondrial dysfunction, and progressive loss of dopaminergic neurons, with no effective disease-modifying treatment available. Sephin1 has been proven to exert protective effects in m...

Xv-shen Ding, Bao Wang, Zheng Han et al. · Biochemical Pharmacology · 0 citations

Review Open access Sep 2026

RNA m6A modification-regulated ferroptosis in cancer: mechanism and therapeutic potential

Empirical evidence elucidating how m6A regulators remodel cystine import, GPX4-dependent antioxidant defense, FSP1 signaling, lipid metabolism, iron handling, autophagy and tumor-microenvironmental communication is synthesized.

Qing-Miao Shi, Yang-Ni Li, Chao Guan · Frontiers in Cell and Develo... · 0 citations