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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Yang Yang

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2 papers indexed here

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Open access Oct 2026

Infection of macrophages by mpox virus activates inflammasome and cell death, informing multitarget therapeutic strategies.

Severe mpox virus (MPXV) infection causes immunopathological manifestations in patients. Here, we provide clinical evidence of MPXV-induced inflammation in a large patient cohort and demonstrate direct macrophage infection in skin tissues from an autopsied mpox patient. In human macrophages, MPXV efficiently enters, re...

Yi-Ning Wang, Xin Wang, T. Tsikari et al. · 0 citations
Open access Sep 2026

Discovery of the nucleoside analogue FMAU as a broad-spectrum anti-orthopoxvirus inhibitor in vitro and in vivo using a structure-guided hit expansion strategy

ABSTRACT Mpox remains a critical public health threat worldwide, and currently available therapeutics against orthopoxvirus infections remain very limited. In this study, we identified 2'-deoxy-2'-fluoro-5-methyl-1-β-D-arabinofuranosyluracil (FMAU) as a broad-spectrum anti-orthopoxvirus candidate through nucleos(t)ide...

Ting-Ting Zheng, Yong Feng, Chang Xu et al. · 0 citations

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