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It is demonstrated that KRAS is a central node in regulating growth factor-induced cell migration, and that KRAS inhibition plays a broader role than MAPK-mediated cell proliferation and survival.
Radioligand therapy (RLT) delivers therapeutic radionuclides to tumor-associated targets through specific targeting ligands and has demonstrated substantial clinical value in malignancies such as prostate cancer and neuroendocrine tumors. Beyond its direct induction of radiation-mediated tumor cell damage, RLT has attr...
This review systematically dissects how dysregulated m6A methylation fuels malignant transformation and progression by reinforcing core oncogenic hallmarks, sustained proliferation, metastasis, metabolic rewiring, and resistance to programmed cell death.
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