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Open access Sep 2026

Glutamine sequestration promotes tumor growth and immune evasion through elevation of arginine methylation in hepatocellular carcinoma

Mechanisms underlying the immunosuppressive microenvironment in hepatocellular carcinoma (HCC) extend beyond immune checkpoints to include metabolic competition. Here, we identify a metabolic evasion pathway driven by SLC1A5 overexpression, which enables HCC cells to sequester glutamine from the tumor microenvironmen...

Jingjing Nian, Zi-Ran Wang, Shi-Yi Chen et al. · 0 citations
Open access Jul 2026

LncRNA MKRN3-AS1 promotes metastasis and autophagy of hepatocellular carcinoma by sponging multiple microRNAs.

Hepatocellular carcinoma is one of the most common malignant tumors with poor clinical outcomes. Increasing numbers of long noncoding RNAs have been shown to be involved in the carcinogenesis and progression of HCC. However, the expressions, clinical significances, and roles of most lncRNAs in HCC are still unknown. In...

Fei Wang, Ji-Zhe Liu, Gaoxiong Wang et al. · 0 citations

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