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Yangfang Yun

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Open access Aug 2026

Structure-guided engineering of an aptamer–PROTAC for targeted degradation of vaccinia-related kinase 1

Vaccinia-related kinase 1 (VRK1) is an oncogenic serine/threonine kinase implicated in tumor progression, yet it remains an intractable target for catalytic degradation. Herein, we report the structure-guided design of a first aptamer–PROTAC chimera for potent and selective degradation of VRK1. Through structure-guided...

Yangfang Yun, Ya-Qing Gao, Yang Shi et al. · 1 citation

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