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Author

Yangyang Zhou

2 papers indexed here

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Open access Jul 2026

Molecular basis of the HPV E7-ZER1 axis reveals a ligandable vulnerability in HPV-positive cancers.

A first-in-class small-molecule inhibitor is identified that blocks E7-ZER1 association, restores Rb stability, and selectively suppresses HPV-positive tumor growth in vivo and nominate the ZER1 degron pocket as a ligandable therapeutic target for HPV-driven malignancies, highlighting translational opportunities for ta...

Xiao-Lu Wang, Chenhao Jiang, Yue-Ling Zhao et al. · 0 citations
Open access Aug 2026

The chromosomal instability associated gene C2orf76 exerts dual roles in colorectal cancer through pyroptosis and chemotherapy response

Introduction Despite advances in colorectal cancer (CRC) treatment, the chromosomal instability (CIN)-positive subgroup remains refractory to conventional therapies and immunotherapy. C2orf76, a poorly characterized gene identified as a CIN-linked candidate in CRC through bioinformatic analyses, has been associated wit...

Li Zhang, Zhu Song, Pin-Jie Zhang et al. · 0 citations

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