Arterial origin-dependent susceptibility of vascular smooth muscle cells to prelamin A-induced senescence and rescue by umbilical artery-derived decellularized extracellular matrix.
OBJECTIVES To determine whether prelamin A (PLA) induces distinct senescence responses in vascular smooth muscle cells (VSMCs) from different arterial origins and whether the extracellular matrix (ECM) modulates these effects. METHODS PLA expression was examined in renal arteries from age-matched patients (59-63 year...