Yanqiu Zhang

Isomucronulatol attenuates liver aging by inhibiting GSK-3β acetylation and promoting β-catenin accumulation

Lycorine alleviates intrahepatic cholestasis by regulating bile acid metabolism via TKT/ATF3/BSEP pathway.

Cholestatic liver disease (CLD) is defined by impaired bile synthesis and excretion, which in turn results in progressive liver injury or fibrosis, however, there are currently no effective therapeutic drugs. Lycorine is an alkaloid isolated from Lycoris bulbs, exhibiting antiviral, anti-inflammatory, analgesic, and ca...

Ligustilide and tectoridin from Danggui Buxue Decoction synergistically attenuate atherosclerosis by targeting the CD36/TRPM2 axis and TNF-α/NF-κB pathway.

BACKGROUND Atherosclerosis (AS) is a common chronic disease and the primary pathological basis for myocardial infarction, stroke, and other disabling conditions. Danggui Buxue Decoction (DBD) is a classic formula in Traditional Chinese Medicine (TCM) normally used for deficiency patterns. However, whether DBD can allev...