GLP-1 receptor agonists and podocyte senescence in diabetic kidney disease: structural pharmacology, mechanistic evidence, and multi-receptor agonism.
Diabetic kidney disease (DKD) is a major cause of chronic kidney disease and kidney failure worldwide. Podocyte senescence is increasingly recognized as a contributor to diabetic glomerular injury, but its importance in human DKD and its modulation by glucagon-like peptide-1 receptor agonists (GLP-1RAs) remain incomple...