Yao-Jia Jiang

Enantioselective Access to Trifluoromethylated Spirocyclopropyl Heterocycles

ABSTRACT Chiral spirocyclopropyl heterocycles have emerged as privileged three‐dimensional structural motifs in medicinal chemistry. Nevertheless, efficient catalytic enantioselective assembly of such compounds still faces considerable synthetic difficulties. Herein, we describe a rhodium‐mediated asymmetric [2+1] cycl...