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Yao-Jin Huang

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Open access Oct 2026

Single-cell CRISPR screen maps epigenetic regulators of lineage specification and malignancies in human HSPCs.

Mapping how genetic perturbations influence cell fate is key to understanding human development and disease. Here, we developed a massively parallel single-cell CRISPR (scCRISPR) screening platform in primary human hematopoietic stem and progenitor cells (HSPCs), profiling 322 regulators across 172,382 single-perturbed...

Shi-Ru Yuan, Shang-Da Yang, Yao-Jin Huang et al. · 0 citations
Open access Sep 2026

The lifelong transcriptomic landscape of human blood cells.

A panoramic landscape of the human hematopoietic system is established and its lifelong behaviors are elaborated, in which a steady-state reference enabled the delineation of pathological hallmarks across hematological malignancies.

Xiao-Wei Xie, Lian-Shuo Li, Fang Hong et al. · 0 citations

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