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Yao-Xun Zeng

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Open access Oct 2026

A DNA G-Quadruplex-Targeting Ligand Suppresses c-MYC Expression: Implications for Gemcitabine‑Resistant Pancreatic Cancer.

The MYC oncogene is dysregulated in nearly 70% of human cancers and plays a central role in tumor initiation and progression. However, direct targeting of c-MYC remains challenging because of its "undruggable" nature. Stabilization of DNA G-quadruplex (G4) structures within the c-MYC promoter offers an alternative stra...

Bo-Xin Zheng, Ya-Kun Wang, Ze-Xin Chen et al. · 0 citations

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