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Author

Yao Yao

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Open access Aug 2026

Loss of laminin-γ1 in pericytes impairs microvascular function and cognition.

Blood-brain barrier (BBB) disruption correlates with lesion burden and cognitive dysfunction in cerebral small vessel disease (CSVD). Laminin, highly produced by pericytes in the brain, maintains BBB integrity. However, it remains unclear if laminin dysregulation contributes to the pathogenesis of CSVD. Here, we show t...

Jingsong Ruan, Ava Nasrollahi, Cecilia G. Martin et al. · 0 citations
Open access Sep 2026

Extracellular vesicles from specific muscle progenitor cells as a novel therapeutic strategy for sarcopenia

Sarcopenia, characterized by age-related loss of skeletal muscle mass and function, poses a significant challenge to lifelong health and wellbeing. Currently, no effective therapeutic interventions exist. In previous work, we developed specialized muscle progenitor cells (MPCs), termed Givi-MPC, from human induce...

Bi Zhao, Yao Yao, Hong Shi et al. · 0 citations

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