The crosstalk between PFKFB3 and RSPO2 drives sepsis-induced lung injury by coupling metabolic rewiring to macrophage inflammation.
Aberrantly activated macrophages drive acute lung injury (ALI), but how metabolic reprogramming fuels their dysfunction remains elusive. Here, we investigated PFKFB3, a glycolytic enzyme converting fructose-6-phosphate to fructose-2,6-bisphosphate, in ALI. PFKFB3 was upregulated both in LPS-stimulated macrophages and s...