The abnormal accumulation of amyloid-beta (Aβ) triggers cellular dysfunction and tissue damage through processes including reactive oxygen species (ROS) and neuroinflammation, ultimately leading to the manifestation of AD symptoms. However, existing studies have revealed that the isolated clearance of amyloid-beta (Aβ)...
Pian Yu, Mei Jiang, Zi-Xiong Qiu et al.· ACS Applied Materials and In...· 0 citations
This review describes how spliceosome assembly, splicing regulatory elements, splicing factors, epigenetic modifications, and post-transcriptional processes determine splice-site selection and suggests that safe clinical translation will require greater selectivity, reduced off-target toxicity, and preservation of esse...
Huining Huang, Yao Yu, Qian Zhou et al.· Molecular Biomedicine· 0 citations
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