Aug 2026
The Paternò-Büchi Reaction Diversifies Rifamycin Scaffolds and Enhances Antibacterial Activity.
Rifamycins display structural diversity and broad bioactivities, with the intrinsic reactivity of their polyketide chain and quinone ring providing a foundation for photochemical reactions. Herein, we constructed the mutant strain Δrif-orf3_16::rifR+rif-orf19 by deleting post-PKS modification genes of rifamycin, yieldi...
Feng Ye, Xinyu Ma, Zhan Li et al.
· Organic Letters · 0 citations