Open access
Aug 2026
Mitophagy Facilitates Cytosolic Proteostasis to Preserve Cardiac Function
Background: Protein quality control (PQC) is critical for maintaining sarcomere structure and function in cardiomyocytes. Mutations in PQC pathway proteins, namely CRYAB-R120G (arginine to glycine at position 120) and BAG3-P209L (proline to lysine at position 209) induce protein aggregates and cardiomyopathy in humans....
David R. Rawnsley, Moydul Islam, Chen Zhao et al.
· Circulation Research · 0 citations