Beyond mean heart dose: quantitative impact of sub-structure spatial dosimetrics on subclinical myocardial strain in thoracic radiotherapy
Purpose To evaluate the spatial dosimetric relationships between cardiac substructures and hyper-acute subclinical myocardial strain alterations after thoracic intensity-modulated radiotherapy (IMRT). Methods Forty patients with thoracic malignancies were prospectively enrolled. Two-dimensional speckle-tracking echocar...