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Author

Yasuhiko Kizuka

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Open access Sep 2026

Species-specific disordered regions and temperature dependence of bisecting GlcNAc-synthetic enzyme MGAT3.

MGAT3 (GnT-III) is a glycosyltransferase that catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the central β-mannose in N-glycans, generating bisecting GlcNAc. These bisecting GlcNAc-bearing N-glycans are implicated in cancer and Alzheimer's disease and negatively regulate N-glycan maturation. Although the bio...

Wan-Xue Bao, Shunji Natsuka, A. Harduin-lepers et al. · 0 citations
Open access Aug 2026

Bisecting GlcNAc in N-glycan regulates synaptic maturation.

It is suggested that bisecting GlcNAc plays important roles in synaptic maturation, highlighting a new mechanism for neuronal activity regulated by specific N-glycans.

Yuta Hashimoto, Wan-Xue Bao, Shun Yamaguchi et al. · 0 citations

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