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Author

Yasushi Sakata

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2 papers indexed here

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Open access Oct 2026

Evaluation of desmosome dynamics using iPS cell-derived cardiomyocytes identifies neddylation inhibitor as a modifier of relaxation in arrhythmogenic cardiomyopathy

Arrhythmogenic cardiomyopathy (ACM) is a hereditary disease caused by desmosomal haploinsufficiency and associated with heart failure and sudden cardiac death. Disease-modifying therapies targeting the underlying molecular mechanisms remain limited. Isogenic-induced pluripotent stem cell–derived cardiomyocytes...

Cong-Cong Sun, Hiroyuki Inoue, Shuichiro Higo et al. · 0 citations
Open access Aug 2026

Longitudinal Transcriptomic Analysis Identifies Persistent Immune-Related Signature Associated With Restrictive Left Ventricular Filling Patterns After Heart Transplantation.

BACKGROUND Diastolic dysfunction is a recognized chronic allograft complication, and a restrictive left ventricular filling pattern is associated with adverse outcomes. However, the underlying pathophysiological mechanisms remain unclear. METHODS AND RESULTS This study included 32 heart transplant recipients with a n...

Kosuke Takahari, Tatsuya Shiraki, H. Kioka et al. · 0 citations

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