Author

Yasuyuki Ohkawa

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Open access Sep 2026

Cryo-EM structures of CENP-A nucleosomes isolated from human cells

Centromeres ensure accurate chromosome segregation, and their identity is specified epigenetically by the histone H3 variant CENP-A. Although the structures of reconstituted CENP-A nucleosomes have provided important insights, how this epigenetic mark is structurally organized within native chromatin remains incomplete...

Eisho Tanida, Suguru Hatazawa, Takumi Oishi et al. · Communications Biology · 0 citations

Open access Sep 2026

Cohesin prevents local mixing of condensed euchromatic domains in living human cells

The human genome is folded into chromatin loops by the cohesin complex, forming functional chromatin domains that underlie transcription and DNA replication/repair. However, how cohesin organizes these domains in living cells, especially in active euchromatin, remains elusive. Here, to address this question, we combine...

Masa A. Shimazoe, Shiori Iida, Katsuhiko Minami et al. · Nature Genetics · 12 citations