Abstract A049: Rational grafting of p53TAD onto CTPR scaffolds generates potent p53-MDM2 antagonists Yawei Qi1, Albert Perez-Riba1, Laura S. Itzhaki11Department of Pharmacology, University of Cambridge, Cambridge, UK
Rational grafting of p53TAD onto CTPR scaffolds generates potent p53-MDM2 antagonists and establishes CTPR proteins as highly engineerable scaffolds for peptide-motif grafting and expand the toolkit of protein-based antagonists for targeting oncogenic protein–protein interactions, potentially opening up new therapeutic...