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Yawei Qi

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Jul 2026

Abstract A049: Rational grafting of p53TAD onto CTPR scaffolds generates potent p53-MDM2 antagonists Yawei Qi1, Albert Perez-Riba1, Laura S. Itzhaki11Department of Pharmacology, University of Cambridge, Cambridge, UK

Rational grafting of p53TAD onto CTPR scaffolds generates potent p53-MDM2 antagonists and establishes CTPR proteins as highly engineerable scaffolds for peptide-motif grafting and expand the toolkit of protein-based antagonists for targeting oncogenic protein–protein interactions, potentially opening up new therapeutic...

Yawei Qi, Laura S. Itzhaki · 0 citations

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