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Review Open access Sep 2026

The role of intestinal microbial metabolites in polycystic ovary syndrome: mechanistic insights and intervention prospects

Polycystic ovary syndrome (PCOS) is a prevalent endocrine-metabolic disorder among women of reproductive age, defined by the core features of hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology. PCOS is frequently complicated by insulin resistance, obesity, dyslipidemia, and chronic low-grade...

Ye Gao, Lin-Lin Fan, Rui Ma et al. · 0 citations
Review Open access Sep 2026

Decoding SUMOylation as a metabolic stress sensor in aging and age-related disorders: mechanisms, tissue specificity and therapeutic potential.

SUMOylation is a reversible post-translational modification increasingly recognized for its role in coordinating cellular responses to metabolic stress during aging. Emerging evidence indicates that it functions beyond a conventional modification, representing an adaptive stress‑responsive regulatory network that integ...

Xin-Yue Liu, Shuang Chen, Dong-Can Liu et al. · 0 citations

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