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Open access Sep 2026

CircRNA Profiling Identifies hsa_circRNA_003201 Associated with a Predicted NLRX1-Related Regulatory Network in an Acne-Associated Inflammatory Sebocyte Model

A circRNA expression profile in an acne-like inflammatory sebocyte model is provided and hsa_circRNA_003201 is identified as a candidate circRNA associated with acne-associated inflammation and suggest a potential circRNA-miRNA-mRNA regulatory network involving NLRX1.

Meng-Jie Fan, Jin Chen, Yang-Fan Lai et al. · 0 citations
Jul 2026

Lipase GehA functions as a positive-feedback amplifier of Cutibacterium acnes-sebum interactions in acne pathogenesis.

It is demonstrated that culturing C. acnes in an artificial sebum system enhances bacterial growth and augments inflammatory, lipogenic, and hyperkeratinization-related responses in keratinocytes, sebocytes, and a Syrian hamster flank organ model.

Yang-Fan Lai, Meng-Jie Fan, Xiaoyao Fan et al. · 1 citation

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