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Open access Sep 2026

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

ABSTRACT Lipid nanoparticles (LNPs) have enabled the clinical application of RNA therapeutics, including approved mRNA vaccines and siRNA medicines. However, their predominant accumulation in liver after systemic administration and inefficient endosomal escape remain key bottlenecks for productive cytosolic delivery an...

Seong Gi Lim, Min-Ju Lee, Yiming Wang et al. · 0 citations
Aug 2026

Photochemistry-Based Development of Ionizable Lipid Library for mRNA-Lipid Nanoparticle Delivery In Vivo.

A photochemistry-based ionizable lipid library (PILL) platform that enables the rapid discovery of ionizable lipids for mRNA delivery and provides a versatile framework for the development of next-generation LNP systems for nucleic acid therapeutics is reported.

Simin Chun, Hyorim Nam, Donghyun Lee et al. · 0 citations

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