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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Yemisi Omotoyosi Adetayo

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Review Open access Sep 2026

Extrachromosomal DNA in Adaptive Tumour Evolution: Mechanisms Driving Plasticity, Drug Resistance and Precision Oncology

Extrachromosomal DNA (ecDNA) has been identified as a critical component of tumour evolution, offering a dynamic genetic and regulatory landscape through which cancer cells can alter oncogene dosage, transcriptional states, and cellular phenotypes. Lacking centromeric and telomeric sequences, ecDNA is inherited in a no...

Verity Ghansah, Yemisi Omotoyosi Adetayo, Oluwabukunmi M. Oluwaniran et al. · 0 citations

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