BACKGROUND
Thiopurines are important therapeutic agents for patients with inflammatory bowel disease (IBD), and the Nudix hydrolase 15 (NUDT15) gene has been reported to be associated with the safety of thiopurine use. We investigated the prevalence of NUDT15 variants and their impacts in the pediatric-onset IBD group...
Wei-Ting Chen, Yung-Li Yang, Chih-Hsiang Yu et al.· Pediatrics and Neonatology· 0 citations
BACKGROUND
Biliary atresia (BA) is the leading cause of pediatric liver transplantation worldwide. However, the genetic background remains unclear in most patients. In this genome-wide association study (GWAS), we aimed to identify genetic loci that contribute to susceptibility to BA.
METHODS
We recruited 189 BA pati...
Chieh-Yu Chu, Chi-San Tai, Chien-Ting Hsu et al.· Pediatrics International· 0 citations
The therapeutic potential of VCM in cholestasis is highlighted by enriching PG in the gut and improving biliary structures in the liver, identifying PG as a potential probiotic with beneficial effects in cholestasis.
Shu-Hao Hsu, Huey‐Huey Chua, Bang‐Yu Liou et al.· Journal of Pathology· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.