Aug 2026
Vincristine enhances doxorubicin cardiotoxicity in human iPSC-derived cardiomyocytes: Partial attenuation by SGLT2 inhibition.
BACKGROUND Doxorubicin is a well-known cardiotoxic chemotherapeutic agent. Whether its combination with vincristine exacerbates cardiotoxicity and the underlying mechanisms remains unclear. METHODS Human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) were treated with doxorubicin, vincristine, or bot...
Hsien-Yuan Chang, Hsiao-Chu Hsu, Yi-Hsien Fang et al.
· Toxicology and Applied Pharm... · 0 citations