Open access
Sep 2026
eNAMPT-IFITM3 axis links neuroinflammation to γ-secretase activation
Summary Amyloid-β (Aβ) accumulation and neuroinflammation are central features of Alzheimer’s disease (AD), yet the molecular link connecting inflammatory signaling to γ-secretase activation remains poorly understood. Here, using a cell-based gain-of-function screen with a cDNA library, we identify nicotinamide phospho...
J. Hyun, Sun-Min Jung, Yoona Noh et al.
· iScience · 0 citations