Yetunde I Kayode

Glucose Metabolism Mediates Feedback Control of Innate Immune Signaling in Human Macrophages

It is demonstrated that glycolysis and PFKFB3 activity are required for NF-κB p65 expression and activation, and inhibition of PFKFB3 also suppressed LPS-induced STAT1 activation and nuclear translocation, revealing a glucose-dependent amplification loop that potentiates STAT1-mediated antiviral and NF-κB p65-mediated...