Open access
Oct 2026
Rational mRNA Structure-guided Attenuation Enables Embryo-safe in-ovo NDV Vaccination and Protection
Newcastle disease virus (NDV) continues to cause major economic losses in poultry, driving many recent virulent outbreaks. Maternally derived antibodies (MDA) can interfere with the development of active immunity following vaccination in young chicks. NDV vaccine strains that are safe for day-old chicks are not safe fo...
T. Tuller, Zohar Zafrir, Dana Goldenberg et al.
· bioRxiv · 0 citations