Author

Yi Chen

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Review Open access Aug 2026

Immune niches in brain tumors: glial–immune cell interactions and spatial microdomains

The immune microenvironment of brain tumors is characterized by remarkable diversity, where immune cells are not randomly distributed but are systematically organized into specific spatial microdomains. This spatial order is primarily orchestrated by glial cells, including astrocytes, microglia, and oligodendrocyte-lin...

Qian Guo, Si-Hang Shen, Zhou-Yuan Zhang et al. · Acta Neuropathologica Commun... · 1 citation

Review Open access Aug 2026

Post-translational modification-governed immune states in cancer immunity: Biomarker implications for checkpoint competence, tumor visibility and immunotherapy resistance (Review)

Immune escape and therapeutic resistance remain major obstacles to durable benefit from cancer immunotherapy, yet transcript-based or abundance-based biomarkers often fail to capture the regulatory states that determine effective immune control. Post-translational modifications (PTMs) form a dynamic protein-state layer...

Jing-Hao Pan, Bo-Yang Li, Ruo-Nan Lin et al. · International Journal of Onc... · 0 citations

Review Sep 2026

Metabolic and epigenetic plasticity of tumor-associated macrophages shapes immunosuppressive outputs and immune checkpoint response.

Immune checkpoint blockade (ICB) has transformed cancer therapy, but durable responses are frequently limited by tumor microenvironment-driven resistance. Tumor-associated macrophages (TAMs) are central mediators of this process because they sense metabolic stress and convert it into immunosuppressive programs that res...

Jing-Hao Pan, Bo-Yang Li, Lucy Yue Lau et al. · Biochimica et biophysica act... · 0 citations